INHIBITORY AND STIMULATORY EFFECTS OF CONCANAVALIN A ON THE RESPONSE OF MOUSE SPLEEN CELL SUSPENSIONS TO ANTIGEN
Open Access
- 1 December 1973
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 138 (6), 1496-1505
- https://doi.org/10.1084/jem.138.6.1496
Abstract
The addition of concanavalin A to mouse spleen cell suspensions can either inhibit or stimulate the immune response to heterologous erythrocytes according to the experimental conditions. Evidence is presented which is incompatible with the hypothesis that these two effects are mediated by a single cell and which favors the hypothesis of separate inhibitor and stimulatory cells.Keywords
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