Aromatic Amines II. Demonstration of 2-amino-1-naphthyl Glucuronides as Metabolite of 2-naphthylamine in Dog Urine.

Abstract

2-Amino-l-naphthyl glucuronide was demonstrated to be a urinary metabolite in dogs fed 2-naphthylamine by identification of the material with the aid of chromatography and enzymatic techniques; 3.5 to 13.3% of ingested dose was excreted in this form when dogs were fed 1 g/day. The possible relation of this glucuronide to bladder cancer is discussed.