Twenty children with severe nocturnal enuresis and widely varying degrees of emotional maladjustment were treated with a conditioning device. The method proved effective in either entirely eliminating or markedly improving the enuresis in 15 of the children, regardless of their emotional status prior to treatment. None of the children appeared to suffer significant undesirable effects as a result of therapy, and beneficial effects, other than improvement in the status of the enuresis, appeared to be confined to the subjective impressions of some of the mothers. Adverse behavior encountered during treatment indicated a need for judicious supervision of therapy along with the cooperation of patients.