Plasma clearance of fat emulsion during continuous heparin infusion
- 1 April 1987
- journal article
- research article
- Published by Wiley in Acta Anaesthesiologica Scandinavica
- Vol. 31 (3), 189-192
- https://doi.org/10.1111/j.1399-6576.1987.tb02547.x
Abstract
Intravenous fat tolerance was tested in two groups of patients given a continuous i.v. infusion of heparin for several days. One group of 11 patients with deep vein thrombosis (DVT) of the leg was given 25000-35000 IU heparin daily for 4-5 days. The other group comprised 10 patients who had central venous catheters (CVC) for total parenteral nutrition. These patients were given 20000 IU heparin daily for 6 days as prophylaxis against CVC-related thrombosis. In the DVT group heparinization was associated with a 44% decrease in plasma fat removal capacity (P < 0.05). This reduction persisted for 2 days after the discontinuation of heparin therapy. In the CVC group the plasma fat removal capacity decreased by 29% during heparinization (P > 0.05, NS). During heparinization activated partial thromboplastin time was more than three times the basal value in the DVT group but less than twice those in the CVC group. One week after the heparin therapy the serum triglyceride levels were higher in both groups compared with initial values (DVT groups: 1.2 .+-. 0.2 s.e.mean vs. 17 .+-. 0.3 mmol/l; P < 0.05. CVC group: 1.0 .+-. 0.1 vs. 1.4 .+-. 0.2 mmol/l; NS). The possibility that full-dose heparinization reduces plasma fat removal capacity and that this may be due to a partial depletion of lipoprotein lipase stores is discussed.Keywords
This publication has 16 references indexed in Scilit:
- Hemodialysis and Cell Toxicity in Vitro Related to Plasma Triglycerides, Post‐heparin Lipolytic Activity and Free Fatty AcidsActa Medica Scandinavica, 1984
- Effect of Heparin on Lipoprotein Profile During Parenteral Fat InfusionsJournal of Parenteral and Enteral Nutrition, 1983
- Reduction of Catheter-Associated Thrombosis in Parenteral Nutrition by Intravenous Heparin TherapyArchives of Surgery, 1982
- Diagnosis of Thrombosis by Catheter Phlebography after Prolonged Central Venous Ca theterizationAnnals of Surgery, 1981
- Fat clearance before and after heparin in chronic renal failure—Haemodialysis reduces post-heparin fractional clearance rates of intralipidClinica Chimica Acta; International Journal of Clinical Chemistry, 1980
- Heparin, free fatty acids and an increased metabolic demand for oxygenPostgraduate Medical Journal, 1980
- A Methodological Study of an Intravenous Fat Tolerance Test with IntralipidREmulsionScandinavian Journal of Clinical and Laboratory Investigation, 1972
- Fibrin Sleeve Formation on Indwelling Subclavian Central Venous CathetersArchives of Surgery, 1971
- HypertriglyceridemiaNew England Journal of Medicine, 1968
- RELATION BETWEEN SERUM-FREE-FATTY-ACIDS AND ARRHYTHMIAS AND DEATH AFTER ACUTE MYOCARDIAL INFARCTIONThe Lancet, 1968