The Importance of Sex in the Variability of the Cholesteremic Response of Rabbits Fed Cholesterol
- 1 July 1956
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 4 (4), 406-412
- https://doi.org/10.1161/01.res.4.4.406
Abstract
Cholesterol feeding studies revealed that the wide variability of cholesteremic response of rabbits is in part sex determined. Male rabbits display lower cholesterol levels both before and after cholesterol feeding. Estradiol treatment of selected rabbits fed cholesterol augmented their cholesteremic response; testosterone treatment had an opposite effect. Ovariectomy lowered while orchidectomy augmented the cholesteremic response of rabbits fed cholesterol; castration tended to diminish the wide variability of cholesteremic response previously observed among intact rabbits.Keywords
This publication has 5 references indexed in Scilit:
- Spontaneous Atherosclerosis in the RabbitCell Metabolism, 1952
- A SIMPLIFIED METHOD FOR THE ESTIMATION OF TOTAL CHOLESTEROL IN SERUM AND DEMONSTRATION OF ITS SPECIFICITYJournal of Biological Chemistry, 1952
- AGE AND WEIGHT AS FACTORS IN THE DEVELOPMENT OF EXPERIMENTAL CHOLESTEROL ATHEROSCLEROSIS IN RABBITS1947
- EFFECT OF TESTOSTERONE PROPIONATE, ESTRADIOL BENZOATE AND DESOXYCORTICOSTERONE ACETATE ON THE KIDNEYS OF ADULT RATS11Endocrinology, 1941
- THE INFLUENCE OF THYROIDECTOMY, SPLENECTOMY, GONADECTOMY, AND SUPRARENALECTOMY UPON THE DEVELOPMENT OF EXPERIMENTAL ATHEROSCLEROSIS IN RABBITSThe Journal of Experimental Medicine, 1927