The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Induces Growth Inhibition and Enhances Gemcitabine-Induced Cell Death in Pancreatic Cancer
- 1 January 2007
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 13 (1), 18-26
- https://doi.org/10.1158/1078-0432.ccr-06-0914
Abstract
Purpose: Pancreatic cancer is an aggressive human malignancy that is generally refractory to chemotherapy. Histone deacetylase inhibitors are novel agents that modulate cell growth and survival. In this study, we sought to determine whether a relatively new histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), inhibits pancreatic cancer cell growth.Keywords
This publication has 52 references indexed in Scilit:
- Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancerNature Reviews Cancer, 2006
- Restoration of Smad4 in BxPC3 Pancreatic Cancer Cells Attenuates Proliferation without Altering AngiogenesisClinical & Experimental Metastasis, 2005
- Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3Blood, 2005
- The Mechanism of the Anti-Tumor Activity of the Histone Deacetylase Inhibitor, Suberoylanilide Hydroxamic Acid (SAHA)Cell Cycle, 2004
- Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cellsOncogene, 2003
- Molecular prognostic markers in pancreatic cancerJournal of Hepato-Biliary-Pancreatic Surgery, 2002
- Resistance to Fas-mediated apoptosis: activation of Caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILPOncogene, 1998
- Fibroblast growth factor-5 stimulates mitogenic signaling and is overexpressed in human pancreatic cancer: evidence for autocrine and paracrine actionsOncogene, 1997
- Alterations in the tumor suppressor genesp53, RB, p16/MTS1, andp15/MTS2 in human pancreatic cancer and hepatoma cell linesThe Esophagus, 1997
- Pancreatic CarcinomaNew England Journal of Medicine, 1992