Laboratory identification of lupus anticoagulants
Open Access
- 31 March 2009
- journal article
- test of-the-month
- Published by Wiley in American Journal of Hematology
- Vol. 84 (7), 440-442
- https://doi.org/10.1002/ajh.21417
Abstract
Lupus anticoagulants (LA) are acquired autoantibodies that can cause antiphospholipid syndrome. LAs prolong phospholipid-dependent coagulation tests, acting as nonspecific inhibitors that are neutralized in the presence of excess phospholipid. However, there is no gold standard test and the testing is influenced by a number of variables. This article summarizes laboratory testing for LAs, with particular focus on technical issues and limitations of testing. Am. J. Hematol. 2009.Keywords
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