Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren syndrome in salivary glands of non-obese diabetic mice
Open Access
- 1 January 2009
- journal article
- Published by Springer Science and Business Media LLC in Arthritis Research & Therapy
- Vol. 11 (1), R24
- https://doi.org/10.1186/ar2617
Abstract
The lymphotoxin-beta receptor (LTβR) pathway is important in the development and maintenance of lymphoid structures. Blocking this pathway has proven beneficial in murine models of autoimmune diseases such as diabetes and rheumatoid arthritis. The aim of this study was to determine the effects of LTβR pathway blockade on Sjögren syndrome (SS)-like salivary gland disease in non-obese diabetic (NOD) mice.Keywords
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