Antigens ofCorynebacterium pseudotuberculosisand prospects for vaccine development
- 1 February 2009
- journal article
- review article
- Published by Informa UK Limited in Expert Review of Vaccines
- Vol. 8 (2), 205-213
- https://doi.org/10.1586/14760584.8.2.205
Abstract
Corynebacterium pseudotuberculosis continues to cause considerable economic losses in ovine and caprine herds worldwide, causing caseous lymphadenitis. Nevertheless, the immunology of this disease is relatively unknown. Novel antigens may provide vaccines that are more effective and improve diagnostic methods for better control of this disease. The available commercial vaccines are not able to fully protect susceptible animals, cannot be used in all host species and are not licensed for use in many countries. Recent studies on the genomics of C. pseudotuberculosis and on its molecular determinants of virulence should bring us new alternatives for more effective vaccine formulations.Keywords
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