A facile approach for the fabrication of core–shell PEDOT nanofiber mats with superior mechanical properties and biocompatibility
- 29 January 2013
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of Materials Chemistry B
- Vol. 1 (13), 1818-1825
- https://doi.org/10.1039/c3tb00448a
Abstract
The development of modern biomedical nanotechnology requires conductive polymeric nanofibers with excellent mechanical and biocompatible properties to meet the needs of practical applications in complex biological systems. In the study, we developed a novel facile method to fabricate poly(3,4-ethylenedioxythiophene) (PEDOT) nanofiber mats by electrospinning combined with in situ interfacial polymerization. The PEDOT nanofiber mats displayed superior mechanical properties (tensile strength: 8.7 ± 0.4 MPa; Young's modulus: 28.4 ± 3.3 MPa) and flexibility, which can almost be restored to its original shape even after serious twisting and crimping. Especially, from the results of the cellular morphology and proliferation of human cancer stem cells (hCSCs) cultured on the PEDOT nanofiber mats for 3 days, evidence was provided that the PEDOT nanofiber mats have similar biocompatibility to tissue culture plates (TCPs). Combined with an outstanding electrical conductivity of 7.8 ± 0.4 S cm−1, these excellent mechanical and biocompatible properties make the PEDOT nanofiber mats promising candidates in biotechnology applications, such as electroactive substrates/scaffolds for tissue engineering, drug delivery, cell culture, and implanted electrodes.Keywords
This publication has 56 references indexed in Scilit:
- Fabrication of conducting electrospun nanofibers scaffold for three-dimensional cells cultureInternational Journal of Biological Macromolecules, 2012
- Fabrication and characterization of a novel fluffy polypyrrole fibrous scaffold designed for 3D cell cultureJournal of Materials Chemistry, 2012
- Preparation of Polymeric Nanoscale Networks from Cylindrical Molecular BottlebrushesACS Nano, 2012
- Design and Preparation of Porous PolymersChemical Reviews, 2012
- State of the Art of Carbon Nanotube Fibers: Opportunities and ChallengesAdvanced Materials, 2012
- Synthesis and applications of one-dimensional semiconductorsProgress in Materials Science, 2010
- A Conducting‐Polymer Platform with Biodegradable Fibers for Stimulation and Guidance of Axonal GrowthAdvanced Materials, 2009
- Conductive Core–Sheath Nanofibers and Their Potential Application in Neural Tissue EngineeringAdvanced Functional Materials, 2009
- Multifunctional Nanobiomaterials for Neural InterfacesAdvanced Functional Materials, 2009
- Conducting polymers for neural interfaces: Challenges in developing an effective long-term implantBiomaterials, 2008