Effects of Calcium, Strontium, and Barium Ions on Phosphorylation of Hippocampal Proteins In Vitro

Abstract
Ca2+ alone or in the presence of added calmodulin stimulated in vitro transfer of 32P from [.gamma.32P]ATP into several proteins of mitochondrial and synaptosomal particulate fractions from rat brain. Sr2+ was capable of substituting for Ca2+ in this stimulation, but Ba2+ lacked this capacity. Ca-dependent protein phosphorylation of synaptic proteins may or may not be intrinsic to neurotransmitter release during neurotransmission.

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