Chronic treatment with interleukin-1 beta induces coronary intimal lesions and vasospastic responses in pigs in vivo. The role of platelet-derived growth factor.
Open Access
- 1 February 1996
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 97 (3), 769-776
- https://doi.org/10.1172/jci118476
Abstract
Studies in vitro have suggested that inflammatory cytokines may play an important role in the pathogenesis of atherosclerosis. However, little is known about their effects in vivo. Thus, the present study was designed to determine in vivo what histological and functional changes may be induced by chronic treatment with IL-1 beta, one of the major inflammatory cytokines, and also to clarify what mechanisms are involved in those changes. Under aseptic conditions, proximal segments of the left porcine coronary arteries were gently wrapped with cotton mesh absorbing Sepharose beads either with or without recombinant human IL-1 beta. From 1 to 4 wk after the operation, coronary vasospastic responses to intracoronary serotonin or histamine were noted at the IL-1 beta-treated site but not at the control site. Histologically, intimal thickening was greater at the IL-1 beta-treated site than at the control site. Those functional and histological changes induced by the chronic treatment with IL-1 beta were significantly inhibited by the simultaneous treatment with a neutralizing antibody to either IL-1 beta or PDGF. These results indicate that chronic treatment with Il-1 beta induces coronary intimal lesions and vasospastic responses in porcine coronary arteries in vivo and also suggest that these changes are substantially mediated by PDGF.Keywords
This publication has 27 references indexed in Scilit:
- The pathogenesis of atherosclerosis: a perspective for the 1990sNature, 1993
- Clinical characteristics of patients with spontaneous remission of variant angina.Japanese Circulation Journal, 1993
- Mitogenic action of interleukin-1α on vascular smooth muscle cells mediated by PDGFAtherosclerosis, 1990
- Immune mechanisms in atherosclerosis.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1989
- Clinical characteristics and long-term prognosis of patients with variant angina. A comparative study between western and Japanese populationsInternational Journal of Cardiology, 1988
- Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids.JCI Insight, 1988
- Increased Adventitial Mast Cells in a Patient with Coronary SpasmNew England Journal of Medicine, 1985
- Significance of adventitial inflammation of the coronary artery in patients with unstable angina: results at autopsy.Cell Metabolism, 1985
- Coronary Artery Spasm Induced in Atherosclerotic Miniature SwineScience, 1983
- Contribution of dynamic vascular wall thickening to luminal narrowing during coronary arterial constriction.Cell Metabolism, 1980