Tin triflate-mediated total synthesis of circumdatin F, sclerotigenin, asperlicin C, and other quinazolino[3,2-a][1,4]benzodiazepines
- 19 November 2008
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 4,p. 445-447
- https://doi.org/10.1039/b813880j
Abstract
Using tin triflate, as an effective Lewis acid, and microwaves, direct double cyclizations of bis(anthranilate)-containing tripeptide precursors to afford the total syntheses of 7-substituted quinazolino[3,2-a][1,4]benzodiazepinediones (1a–f), including natural products circumdatin F (1a), sclerotigenin (1b), and asperlicin C (1c), were achieved with good overall isolated yields (23–62%).Keywords
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