CHANGES IN THE VOLUME OF THE KIDNEY IN THE INTACT ANIMAL: A PLETHYSMOGRAPHIC STUDY WITH ESPECIAL REFERENCE TO DIURETICS

Abstract

A method for plethysmographic study of the kidney is described. It is an adapta-tion of Hargis'' collodion plethysmograph. Observations were made on virtually intact dogs. Simultaneous trac-ings of carotid bl. press. were made under local anesthesia in some of the animals. The effects of caffeine, theo-bromine sodio-salicylate, theophylline ethylene diamine, pituitrin, digitalis, merbaphen, nitrites, epinephrine, spinal anesthesia and distilled H2O were studied. Results agreed with those of other workers on anesthetized dogs. From 0.5-1 cc. dist. H2O per kgm. produced a temporary but pronounced decrease in volume, without change in blood pressure.