Antioxidant and cytoprotective compounds from Berberis vulgaris (barberry)
- 20 June 2008
- journal article
- research article
- Published by Wiley in Phytotherapy Research
- Vol. 22 (7), 979-981
- https://doi.org/10.1002/ptr.2443
Abstract
Activity-guided fractionation of an EtOAc-soluble partition of the MeOH extract from the root bark of Berberis vulgaris L. (barberry), using a hydroxyl radical-scavenging assay, led to the isolation and identification of three phenolic compounds of a previously known structure, N-(p-trans-coumaroyl)tyramine, cannabisin G and (±)-lyoniresinol. Of these, cannabisin G and (±)-lyoniresinol exhibited antioxidant activity in this bioassay. Furthermore, it was found that cannabisin G showed cytoprotective activity in cultured MCF-7 cells modulated by hydrogen peroxide. Copyright © 2008 John Wiley & Sons, Ltd.Keywords
Funding Information
- The Ohio State University Comprehensive Cancer Center (Cancer Chemoprevention Program)
- Gumma National College of Technology
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