Constitutional Nonhemolytic Hyperbilirubinemia in the Rat: Defect of Bilirubin Conjugation

Abstract

In contrast to similar preparations of normal rat tissue, broken-cell preparations of liver and oi kidney from rats with constitutional nonhemolytic hyper-bilirubinemia failed to synthesize bilirubin or o-aminophenol glu-curonides. Inhibition of [beta]-glucuronidase with potassium saccharate failed to influence conjugation of bilirubin in these animals. The evidence presented suggests that in constitutional nonhemolytic hyper-bilirubinemia in rats, glucuronyl transferase activity is absent or inhibited.