Heritable Fragile Site on Chromosome 16: Probable Localization of Haptoglobin Locus in Man
- 2 October 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 170 (3953), 85-87
- https://doi.org/10.1126/science.170.3953.85
Abstract
We have found recurrent chromosome breaks at a site (the "fragile site") on the long arm of chromosome 16. This site segregates in simple Mendelian dominant fashion in a large family. The distal portion of the chromosome sometimes shows selective endoreduplication. Preliminary linkage results reveal only 3 recombinants in 33 opportunities for recombination between the fragile site and the alpha locus of haptoglobin, an indication that the α-Hp gene is located near this region on chromosome 16.Keywords
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