Intracellular p H of Mitogen-Stimulated Lymphocytes
- 28 May 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 216 (4549), 1009-1010
- https://doi.org/10.1126/science.6281887
Abstract
Mitogenic stimulation of mouse lymphocytes results in two sequential intracellular alkalinizations. The first shift of intracellular pH from 7.18 to 7.35 coincides with early biochemical events following mitogenic stimulation. The second alkalinization begins 12 hours after stimulation and rises in parallel with the rate of thymidine incorporation. The results suggest that intracellular alkalinization following stimulation may play a key role in the enhancement of cellular activation and mitogenesis.This publication has 11 references indexed in Scilit:
- Soluble factor activation of human B lymphocytesNature, 1981
- B-cell activation by helper cells is a two-step processNature, 1981
- B lymphocyte stimulationCell, 1981
- Two distinct factors are required for induction of T-cell growthNature, 1980
- Concanavalin A induces an intraluminal alkalinization of thymocyte membrane vesiclesJournal of Cellular Physiology, 1980
- The role of mitogenic lectins in T-cell triggeringNature, 1979
- Transmembrane electrical and pH gradients across human erythrocytes and human peripheral lymphocytesJournal of Cellular Physiology, 1979
- Intracellular pH: Methods and ApplicationsPublished by Elsevier BV ,1979
- Membrane Cation Transport and the Control of Proliferation of Mammalian CellsAnnual Review of Physiology, 1978
- PPD Tuberculin—a B-Cell MitogenNature New Biology, 1972