Excretion of Urinary Kinin in Man

Abstract

The excretion of urinary kinin was estimated in many patients under various clinical conditions. The results were in good accordance with those reported by Horton, who used another method of assay. Normal excretions were found ranging 10-30μg per day. Patients with renal failure excreted reduced amounts of the kinin. No definite change in the kinin output was proved in patients with derma-tological or neurological diseases, in which the kinin has been discussed to be etiologically involved. This and other indirect evidence suggested that the kinin does not originate from the circulating blood, but is secreted by renal tubular cells.