Comparative Pharmacology of Guinea Pig Cardiac Myocyte and Cloned hERG (IKr) Channel
- 29 November 2004
- journal article
- research article
- Published by Wiley in Journal of Cardiovascular Electrophysiology
- Vol. 15 (11), 1302-1309
- https://doi.org/10.1046/j.1540-8167.2004.04099.x
Abstract
This study used whole-cell, patch clamp techniques on isolated guinea pig ventricular myocytes and HEK293 cells expressing cloned human ether-a-go-go-related gene (hERG) to examine the action of drugs causing QT interval prolongation and torsades de pointes (TdP) in man. Similarities and important differences in drug actions on cardiac myocytes and cloned hERG I(Kr) channels were established. Qualitative actions of the drugs on cardiac myocytes corresponded with results obtained from Purkinje fibers and measurement of QT interval prolongation in animal and human telemetry studies.1669Keywords
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