Alcohol, coffee and tea intake and the risk of cognitive deficits: a dose–response meta-analysis
Open Access
- 11 February 2021
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Psychiatric Sciences
- Vol. 30, e13
- https://doi.org/10.1017/s2045796020001183
Abstract
Aims Lifestyle interventions are an important and viable approach for preventing cognitive deficits. However, the results of studies on alcohol, coffee and tea consumption in relation to cognitive decline have been divergent, likely due to confounds from dose–response effects. This meta-analysis aimed to find the dose–response relationship between alcohol, coffee or tea consumption and cognitive deficits. Methods Prospective cohort studies or nested case-control studies in a cohort investigating the risk factors of cognitive deficits were searched in PubMed, Embase, the Cochrane and Web of Science up to 4th June 2020. Two authors searched the databases and extracted the data independently. We also assessed the quality of the studies with the Newcastle-Ottawa scale. Stata 15.0 software was used to perform model estimation and plot the linear or nonlinear dose–response relationship graphs. Results The search identified 29 prospective studies from America, Japan, China and some European countries. The dose–response relationships showed that compared to non-drinkers, low consumption (11 g/day). Low consumption of coffee reduced the risk of any cognitive deficit (<2.8 cups/day) or dementia (<2.3 cups/day). Green tea consumption was a significant protective factor for cognitive health (relative risk, 0.94; 95% confidence intervals, 0.92–0.97), with one cup of tea per day brings a 6% reduction in risk of cognitive deficits. Conclusions Light consumption of alcohol (<11 g/day) and coffee (<2.8 cups/day) was associated with reduced risk of cognitive deficits. Cognitive benefits of green tea consumption increased with the daily consumption.Keywords
This publication has 52 references indexed in Scilit:
- A Prospective Examination of the Relationship between Physical Activity and Dementia Risk in Later LifeAmerican Journal of Health Promotion, 2012
- Meta-Analysis for Linear and Nonlinear Dose-Response Relations: Examples, an Evaluation of Approximations, and SoftwareAmerican Journal of Epidemiology, 2011
- Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studiesBMJ, 2011
- Coffee drinking in middle age is not associated with cognitive performance in old ageThe American Journal of Clinical Nutrition, 2009
- Facilitating meta‐analyses by deriving relative effect and precision estimates for alternative comparisons from a set of estimates presented by exposure level or disease categoryStatistics in Medicine, 2007
- Fruit and Vegetable Juices and Alzheimer’s Disease: The Kame ProjectAmerican Journal Of Medicine, 2006
- Binge Drinking in Midlife and Dementia RiskEpidemiology, 2005
- Alcohol consumption and its relation to risk factors for cardiovascular disease in the north-west of Russia: the Arkhangelsk studyInternational Journal of Epidemiology, 2005
- Association between Reported Alcohol Intake and Cognition: Results from the Women's Health Initiative Memory StudyAmerican Journal of Epidemiology, 2005
- Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based studyBMJ, 2004