Melatonin counteracts the inhibitory effect of PGE2on IL‐2 production in human lymphocytes via its mt1 membrane receptor
Open Access
- 19 February 2003
- journal article
- fj express-summaries
- Published by Wiley in The FASEB Journal
- Vol. 17 (6), 755-757
- https://doi.org/10.1096/fj.02-0501fje
Abstract
It is well known that melatonin plays a fundamental role in human neuro-immunomodulation. Thus, melatonin regulates the production of a large number of cytokines, including interleukin-2 (IL-2) in th...Keywords
This publication has 50 references indexed in Scilit:
- Melatonin activates Th1 lymphocytes by increasing IL-12 productionLife Sciences, 1999
- Inactivation of Melatonin Receptors by Protein Kinase C in Human Prostate Epithelial CellsEndocrinology, 1997
- Prostaglandin E2Inhibits the Nuclear Transcription of the Human Interleukin 2, but Not the IL-4, Gene in Human T Cells by Targeting Transcription Factors AP-1 and NF-ATCellular Immunology, 1996
- The Aging Immune System: Primer and ProspectusScience, 1996
- Binding of 3H-melatonin to calmodulinLife Sciences, 1993
- Cyclic AMP second messenger systemsCurrent Opinion in Cell Biology, 1991
- Pinealectomy inhibits interleukin-2 production and natural killer activity in miceInternational Journal of Immunopharmacology, 1989
- Prostaglandin E inhibits the production of human interleukin 2.The Journal of Experimental Medicine, 1982
- Regulation of the immune response by prostaglandinsClinical Immunology and Immunopathology, 1980
- Prostaglandins and the immune responseLife Sciences, 1977