Interaction of mastoparan with the low molecular mass GTP‐binding proteins rho/rac
- 21 October 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 291 (2), 336-340
- https://doi.org/10.1016/0014-5793(91)81315-y
Abstract
Mastoparan, which has been shown to active G proteins [1], inhibits the ADP-ribosylation of 20 kDa human platelet membrane proteins catalyzed by Clostridium botulinum exoenzyme C3 half-maximally and maximally (90%) at 20 and 100 μM concentrations, respectively. Inhibition of ADP-ribosylation was enhanced by GTP-γS. Mastoparan increased GTP hydrolysis by porcine brain rho protein and stimulated GTP binding in a concentration dependent manner. The data suggest that mastoparan not only interacts with heterotrimeric G proteins but also with low molecular mass GTP-binding proteins of the rho/rac family.Keywords
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