Urine free-cortisol determination. A useful tool in the management of chronic hypoadrenal states
- 9 April 1982
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 247 (14), 2002-2004
- https://doi.org/10.1001/jama.247.14.2002
Abstract
The clinical value of urine free-cortisol (UFC) determination in the management of hypoadrenal states in patients receiving maintenance glucocorticoid therapy was assessed. Nine patients with primary adrenal insufficiency collected five 24-h urine specimens while taking their usual oral dose of cortisone acetate or hydrocortisone. Each urine sample was assayed for UFC and creatinine. The range of UFC level for the group was from 9.4-43 .mu.g/24 h (10 to 21 .mu.g/g creatinine). For each patient the amount of UFC showed little day-to-day variation, with the coefficient of variation ranging from 8-26%. The UFC values of the patients with hypoadrenalism who were receiving treatment were well within the values of UFC in the control population (523). Four cases illustrating the usefulness of UFC determination in patients receiving an oral maintenance regimen of hydrocortisone or cortisone are presented. The UFC is a useful biochemical marker that correlated clinically with glucocorticoid deficiency or excess in patients with hypoadrenalism receiving maintenance steroid replacement.This publication has 4 references indexed in Scilit:
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- POLY-MALEIC ACID ANHYDRIDE (PMA) COUPLED CORTISOL ANTIBODY IN ROUTINE DETERMINATION OF URINARY FREE CORTISOLActa Endocrinologica, 1979
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- THE DETERMINATION OF CREATINE AND CREATININE IN URINE - A CORRECTION FACTOR FOR THE DETERMINATION OF 24-HOUR URINARY EXCRETION VALUES1954