Epidermal Growth Factors Enhances Viral Transformation of Granulosa Cells
- 10 July 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 213 (4504), 218-219
- https://doi.org/10.1126/science.6264597
Abstract
Kirsten sarcoma virus produced a low incidence of transient morphological transformation in primary cultures of rat ovarian granulosa cells. In the presence of epidermal growth factor, the incidence of transient transformation increased severalfold and two continuous cell lines were established. Epidermal growth factor, a naturally occurring polypeptide hormone, appears to act here as a tumor promoter in the retrovirus-induced transformation of a mesodermally derived epithelium.Keywords
This publication has 13 references indexed in Scilit:
- Synthesis and processing of glycoproteins gD and gC of herpes simplex virus type 1Journal of Virology, 1980
- Sarcoma growth factor from mouse sarcoma virus-transformed cells. Purification by binding and elution from epidermal growth factor receptor-rich cells.Journal of Biological Chemistry, 1980
- Tumor promoters and epidermal growth factor stimulate anchorage-independent growth of adenovirus-transformed rat embryo cellsCell, 1979
- Fibroblast and Epidermal Growth Factors are Mitogenic Agents for Cultured Granulosa Cells of Rodent, Porcine, and Human Origin*Endocrinology, 1979
- Is the product of the src gene a promoter?Proceedings of the National Academy of Sciences of the United States of America, 1979
- Alteration of the growth of cytomegalovirus and herpes simplex virus type 1 by epidermal growth factor, a contaminant of crude human chorionic gonadotropin preparations.JCI Insight, 1978
- Transformation of cultured rat adrenocortical cells by kirsten murine sarcoma virus (ki‐msv)International Journal of Cancer, 1977
- Epidermal growth factor enhancement of skin tumor induction in miceCellular and Molecular Life Sciences, 1976
- Derivation of Mouse Sarcoma Virus (Kirsten) by Acquisition of Genes from Heterologous HostJournal of General Virology, 1975
- Transformation of horse skin cells by type‐c sarcoma virusesInternational Journal of Cancer, 1975