Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana
- 1 February 1996
- journal article
- Published by Microbiology Society in Microbiology
- Vol. 142 (2), 435-440
- https://doi.org/10.1099/13500872-142-2-435
Abstract
Summary: Pestalotiopsis microspora was isolated from the inner bark of a small limb of Himalayan yew, Taxus wallachiana, and was shown to produce taxol in mycelial culture. Taxol was identified by spectroscopic and chromatographic comparisons with authentic taxol. Optimal taxol production occurred after 2-3 weeks in still culture at 23°C. [14C]Acetate and [14C]phenylalanine served as precursors for fungal [14C]taxol. These observations on P. microspora are discussed in relation to the biological importance of taxol production by fungi in general.Keywords
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