Fatal cross infection by carbapenem‐resistant Klebsiella in two liver transplant recipients
Open Access
- 31 May 2009
- journal article
- case report
- Published by Wiley in Transplant Infectious Disease
- Vol. 11 (3), 257-265
- https://doi.org/10.1111/j.1399-3062.2009.00374.x
Abstract
Members of the family Enterobacteriaceae including Klebsiella have re‐emerged as major pathogens in solid organ transplantation. The recent appearance and dissemination of carbapenemase‐producing Enterobacteriaceae in Europe and the northeastern United States represents a major challenge to the treatment of enteric gram‐negative bacterial infections in immunocompromised patients; however, few reports have detailed the outcomes of such infections. Here we report 2 cases of Klebsiella pneumoniae carbapenemase (KPC)‐producing Klebsiella infections in orthotopic liver transplant recipients, which were the index case and initial secondary case for an outbreak of KPC‐producing Enterobacteriaceae in our institution. In both instances, the pathogens were initially misidentified as being carbapenem sensitive, the infections recurred after cessation of directed therapy, and the patients ultimately succumbed to their infections.Keywords
This publication has 38 references indexed in Scilit:
- KPC-2-Producing Enterobacter cloacae and Pseudomonas putida Coinfection in a Liver Transplant RecipientAntimicrobial Agents and Chemotherapy, 2009
- Simple Disk-Based Method for Detection of Klebsiella pneumoniae Carbapenemase-Type β-Lactamase by Use of a Boronic Acid CompoundJournal of Clinical Microbiology, 2008
- Bacteremias in liver transplant recipients: Shift toward gram-negative bacteria as predominant pathogensLiver Transplantation, 2004
- Community-Acquired West Nile Virus Infection in Solid-Organ Transplant Recipients.Transplantation, 2004
- VIM-1 Metallo-β-Lactamase-Producing Klebsiella pneumoniae Strains in Greek HospitalsJournal of Clinical Microbiology, 2003
- A randomized, prospective, double-blinded evaluation of selective bowel decontamination in liver transplantationTransplantation, 2002
- Modified Hodge and EDTA-disk synergy tests to screen metallo-β-lactamase-producing strains of Pseudomonas and Acinetobactet speciesClinical Microbiology & Infection, 2001
- The Compromised Host as Sentinel ChickenNew England Journal of Medicine, 1987
- Effects of Oral Antibiotics on Stool Flora and Overall Sensitivity Patterns in an Intensive Care NurseryPediatric Research, 1982
- Analysis of Increasing Antibiotic Resistance of Klebsiella pneumoniae Relative to Changes in ChemotherapyThe Journal of Infectious Diseases, 1978