Perfluorinated Compounds in Relation to Birth Weight in the Norwegian Mother and Child Cohort Study
Open Access
- 19 April 2012
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 175 (12), 1209-1216
- https://doi.org/10.1093/aje/kwr459
Abstract
Perfluorooctane sulfonate and perfluorooctanoic acid are perfluorinated compounds (PFCs) widely distributed in the environment. Previous studies of PFCs and birth weight are equivocal. The authors examined this association in the Norwegian Mother and Child Cohort Study (MoBa), using data from 901 women enrolled from 2003 to 2004 and selected for a prior case-based study of PFCs and subfecundity. Maternal plasma samples were obtained around 17 weeks of gestation. Outcomes included birth weight z scores, preterm birth, small for gestational age, and large for gestational age. The adjusted birth weight z scores were slightly lower among infants born to mothers in the highest quartiles of PFCs compared with infants born to mothers in the lowest quartiles: for perfluorooctane sulfonate, β = −0.18 (95% confidence interval: −0.41, 0.05) and, for perfluorooctanoic acid, β = −0.21 (95% confidence interval: −0.45, 0.04). No clear evidence of an association with small for gestational age or large for gestational age was observed. Perfluorooctane sulfonate and perfluorooctanoic acid were each associated with decreased adjusted odds of preterm birth, although the cell counts were small. Whether some of the associations suggested by these findings may be due to a noncausal pharmacokinetic mechanism remains unclear.Keywords
This publication has 47 references indexed in Scilit:
- Maternal Concentrations of Polyfluoroalkyl Compounds during Pregnancy and Fetal and Postnatal Growth in British GirlsEnvironmental Health Perspectives, 2012
- Perfluorinated Compounds and Subfecundity in Pregnant WomenEpidemiology, 2012
- Epidemiologic Evidence on the Health Effects of Perfluorooctanoic Acid (PFOA)Environmental Health Perspectives, 2010
- Rate of Decline in Serum PFOA Concentrations after Granular Activated Carbon Filtration at Two Public Water Systems in Ohio and West VirginiaEnvironmental Health Perspectives, 2010
- Correlations between Prenatal Exposure to Perfluorinated Chemicals and Reduced Fetal GrowthEnvironmental Health Perspectives, 2009
- Binding of PFOS to serum albumin and DNA: insight into the molecular toxicity of perfluorochemicalsBMC Molecular Biology, 2009
- The relationship between birth weight, gestational age and perfluorooctanoic acid (PFOA)-contaminated public drinking waterReproductive Toxicology, 2008
- Perfluorinated Chemicals and Fetal Growth: A Study within the Danish National Birth CohortEnvironmental Health Perspectives, 2007
- Cord Serum Concentrations of Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) in Relation to Weight and Size at BirthEnvironmental Health Perspectives, 2007
- Half-Life of Serum Elimination of Perfluorooctanesulfonate,Perfluorohexanesulfonate, and Perfluorooctanoate in Retired Fluorochemical Production WorkersEnvironmental Health Perspectives, 2007