A CLINICAL ROUTINE-METHOD FOR THE QUANTITATIVE DETERMINATION OF GONADOTROPHINS IN 24-HOUR URINE SAMPLES, II: NORMAL VALUES FOR MEN AND WOMEN AT ALL AGE GROUPS FROM PRE-PUBERTY TO SENESCENCE

Abstract

Problems inherent in the numerical expression of urinary gonadotropic activity are discussed. The values are given in mouse uterine units, with the unit controlled by a reference. Assays of this reference against others are presented for comparison of the normal values with findings in the literature. Data for analytical accuracy and the day-to-day variation of excretion of gonadotropins are given. The clinical usefulness of analytical procedure as compared with other methods is discussed. The procedure presents definite advantages for clinical routine use permitting the differential diagnosis of hypo-normo- or hyper-gonadotropic states by means of an analysis of a single 24-hour urine specimen.