Further Studies on the Formation of Bile Acids in the Guinea Pig. Bile Acids and Steroids 141.

Abstract

The conversion of 4-C14-cholesterol to bile acids was studied in 2 strains of guinea pigs, ranging in weight from 250 to 960 g. It was not possible to demonstrate the formation of cholic acid in these animals. Lithocholic acid was identified and ursodeoxycholic acid tentatively identified as minor components of guinea pig bile. Two unidentified neutral steroids, compounds I and II, were isolated from bile. Compound II was converted mainly into chenodeoxycholic acid in the bile fistula rat.