Serum and Salivary IgE, IgA, andAntibodies toDermatophagoides pteronyssinusand Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children
Open Access
- 1 January 2011
- journal article
- research article
- Published by Hindawi Limited in Clinical and Developmental Immunology
- Vol. 2011, 1-11
- https://doi.org/10.1155/2011/302739
Abstract
Allergic rhinitis (AR) is a public health problem with high prevalence worldwide. We evaluated levels of specific IgE, IgA, and IgG4 antibodies to the Dermatophagoides pteronyssinus (Dpt) house dust mite and to its major allergens (Der p1 and Der p2) in serum and saliva samples from allergic and nonallergic children. A total of 86 children were analyzed, from which 72 had AR and 14 were nonallergic healthy children. Serum IgE and serum/salivary IgG4 levels to Dpt, Der p1, and Der p2 were higher in allergic children whereas serum/salivary IgA levels to all allergens were higher in nonallergic children. IgE levels positively correlated with IgG4 and IgA to all allergens in allergic children, while IgA levels negatively correlated with IgG4 to Dpt and Der p1 in nonallergic children. In conclusion, mite-specific IgA antibodies predominate in the serum and saliva of nonallergic children whereas mite-specific IgE and IgG4 are prevalent in allergic children. The presence of specific IgA appears to have a key role for the healthy immune response to mucosal allergens. Also, specific IgA measurements in serum and/or saliva may be useful for monitoring activation of tolerance-inducing mechanisms during allergen specific immunotherapeutic procedures, especially sublingual immunotherapy.Keywords
Funding Information
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
This publication has 35 references indexed in Scilit:
- The Principle of Homologous Groups in Regulatory Affairs of Allergen Products – A ProposalInternational Archives of Allergy and Immunology, 2008
- Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*Allergy, 2008
- Global strategy for asthma management and prevention: GINA executive summaryEuropean Respiratory Journal, 2008
- Comparison of Der p1‐specific antibody levels in children with allergic airway disease and healthy controlsPediatric Allergy and Immunology, 2007
- IgE, IgG1, and IgG4 antibody responses to Blomia tropicalis in atopic patientsAllergy, 2005
- IL‐10 and TGF‐β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapyEuropean Journal of Immunology, 2003
- A sensitive reverse ELISA for the measurement of specific IgE to Der p 2, a major Dermatophagoides pteronyssinus allergenAnnals of Allergy, Asthma & Immunology, 2001
- Differences in titres of IgE, IgG4 and other IgG subclass anti‐ Der p 2 antibodies in allergic and non‐allergic patients measured with recombinant allergenClinical and Experimental Allergy, 1996
- Salivary anti‐RSV IgA antibodies and respiratory infections during the first year of life in atopic and non‐atopic infantsPediatric Allergy and Immunology, 1994
- TRANSIENT IgA DEFICIENCY AND PATHOGENESIS OF INFANTILE ATOPYThe Lancet, 1973