Acetylcholinesterase activity in ventricular and cisternal csf of dogs: Effect of chlorpromazine
- 1 January 1978
- journal article
- research article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 3 (5-6), 335-339
- https://doi.org/10.1002/jnr.490030504
Abstract
Acetylcholinesterase (AChE) activity in dog plasma is significantly higher than in either ventricular or cisternal CSF. However, since protein levels in plasma are about 100-fold higher than in CSF, the specific activity of AChE is lower in plasma than in CSF. Acetylcholinesterase activity in plasma represents only 22% of total cholinesterase (ChE) activity, while preliminary findings indicate that in ventricular CSF it is 50–60%. Acetylcholinesterase activity in ventricular CSF is significantly lower than in cisternal CSF. Chlorpromazine (10 mg/kg, intravenous), a drug which increases acetylcholine turnover, increased AChE-specific activity in all dogs. Our results support the hypothesis of a neuronal origin of AChE activity in CSF.Keywords
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