Outcome of Systemic Lupus Erythematosus a Study of 66 Patients over 7 Years with Special Reference to the Predictive Value of Anti-DNA Antibody Determinations
- 1 January 1991
- journal article
- research article
- Published by Informa UK Limited in Scandinavian Journal of Rheumatology
- Vol. 20 (2), 104-109
- https://doi.org/10.3109/03009749109165284
Abstract
A cohort of 66 patients with SLE that were thoroughly studied, both clinically and serologically in 1980-81, when they had a mean disease duration of eight years, were evaluated seven years later in order to assess the long-range outcome of the disease. Five patients were lost from follow-up and 12 (20%) died during the follow-up. The estimated 10-year survival was 91%. A total of 30 patients (45%), showed no signs of nephritis at any stage, and in only eight an active nephritis was found during the follow-up. The previous antibody determinations, provided no predictive information regarding the behaviour of the renal manifestations. Arthralgia was the main clinical symptom during the follow-up. Hypertension developed in 23%. At the end of the follow-up the disease was regarded as active in 13% of the patients.Keywords
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