Synthesis of 3-[(4-Chloro-phenyl) oxiranyl]thiophen-2-yl-propanone and Their Reactions with Some Nucleophilles for Antiviral Evaluations

Abstract

Compounds 2, 3, 4, 7, 10, 11, 12 and 13 were formed via the reactions of [3-(4-chlorophenyl)oxiranyl]thiophen-2-yl-propanone with hydrazine derivatives, hydroxyl-amine hydrochloride, thiourea, thiosemicarbazide, carbon disulfide, phenyl isothiocyanate, methyl isothiocyanate and phosphorus pentasulfide, respectively. Pyrimidine derivative 4 was in turn used as precursor for preparation of thiazolopyrimidines 5 and 6. Pyrazolothioamide 7 was treated with D-glucose and arbinose to afford the corresponding hydrazones 8 and 9.