The Naturally Attenuated Kunjin Strain of West Nile Virus Shows Enhanced Sensitivity to the Host Type I Interferon Response
- 1 June 2011
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 85 (11), 5664-5668
- https://doi.org/10.1128/jvi.00232-11
Abstract
The host determinants that contribute to attenuation of the naturally occurring nonpathogenic strain of West Nile virus (WNV), the Kunjin strain (WNVKUN), remain unknown. Here, we show that compared to a highly pathogenic North American strain, WNVKUN exhibited an enhanced sensitivity to the antiviral effects of type I interferon. Our studies establish that the virulence of WNVKUN can be restored in cells and mice deficient in specific interferon regulatory factors (IRFs) or the common type I interferon receptor. Thus, WNVKUN is attenuated primarily through its enhanced restriction by type I interferon-and IRF-3-dependent mechanisms.Keywords
This publication has 28 references indexed in Scilit:
- The NS5 Protein of the Virulent West Nile Virus NY99 Strain Is a Potent Antagonist of Type I Interferon-Mediated JAK-STAT SignalingJournal of Virology, 2010
- Induction of IFN-β and the Innate Antiviral Response in Myeloid Cells Occurs through an IPS-1-Dependent Signal That Does Not Require IRF-3 and IRF-7PLoS Pathogens, 2009
- Interferon Regulatory Factor IRF-7 Induces the Antiviral Alpha Interferon Response and Protects against Lethal West Nile Virus InfectionJournal of Virology, 2008
- West Nile Virus Nonstructural Protein 1 Inhibits TLR3 Signal TransductionJournal of Virology, 2008
- Early Production of Type I Interferon during West Nile Virus Infection: Role for Lymphoid Tissues in IRF3-Independent Interferon ProductionJournal of Virology, 2007
- Cell-Specific IRF-3 Responses Protect against West Nile Virus Infection by Interferon-Dependent and -Independent MechanismsPLoS Pathogens, 2007
- Resistance to Alpha/Beta Interferon Is a Determinant of West Nile Virus Replication Fitness and VirulenceJournal of Virology, 2006
- Envelope Protein Glycosylation Status Influences Mouse Neuroinvasion Phenotype of Genetic Lineage 1 West Nile Virus StrainsJournal of Virology, 2005
- The Relationships between West Nile and Kunjin VirusesEmerging Infectious Diseases, 2001
- The Relationships between West Nile and Kunjin VirusesEmerging Infectious Diseases, 2001