STUDIES ON INTRAOSSEOUS INJECTIONS OF EPINEPHRINE

Abstract

Intramuscular and hypodermic injs. of both aqueous and oil solns. of epinephrine exert little or no effect on blood pressure of exptl. animals. Intraosseous injs. of aq. solns. of epinephrine are followed by immediate absorption of the hormone, as indicated by a prompt rise in blood pressure succeeded by a rapid fall to below normal level, effects which are not distinguishable from those following intraven. inj. of such solns. Intramedullar inj. of epinephrine suspensions in oil is followed by a prompt rise in blood pressure to a moderate level, long sustained, the maintenance of the pressure for a long time at that height indicating the slow and continuous absorption of this drug from the bone cavity.