High expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomas
- 19 July 2012
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 65 (11), 1019-1023
- https://doi.org/10.1136/jclinpath-2012-200826
Abstract
Background and aims Molecular target therapy against L-type amino acid transporter 1 (LAT1) is unique and expected to be developed soon. LAT1 expression was investigated in pancreatic cancer as a prognostic predictor. Methods Surgically resected pancreatic ductal adenocarcinomas (PDAC, n=66) were investigated using immunohistochemistry. For reference, intraductal papillary mucinous carcinomas (IPMC, including intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia or with an associated invasive carcinoma, n=13) and adenomas (IPMA, including IPMN with low- and intermediate-grade dysplasia, n=5) were also examined. Results LAT1 expression scores increased from PDAC to IPMA to IPMC. Kaplan–Meier analysis showed significant differences between LAT1-high and -low scores in PDAC. Even in each Ki-67-labelling index (LI) low and high PDAC group (cut off 40%), high LAT1 expression could also predict poor prognosis. Multivariable analysis showed that LAT1 expression, Ki-67 LI, tumour differentiation and size were individual prognostic factors. Conclusions LAT1 aberrant overexpression in PDAC predicts poor prognosis, independent of Ki-67 LI, and offers a potential target for future anticancer therapy with its inhibitors.This publication has 17 references indexed in Scilit:
- Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intentCancer, 2011
- High expression of L‐type amino‐acid transporter 1 (LAT1) in gastric carcinomas: Comparison with non‐cancerous lesionsPathology International, 2011
- l‐Type amino acid transporter 1 inhibitors inhibit tumor cell growthCancer Science, 2009
- L‐type amino acid transporter 1 expression is a prognostic marker in patients with surgically resected stage I non‐small cell lung cancerHistopathology, 2009
- Prognostic significance of l-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinomaLung Cancer, 2009
- L‐type amino‐acid transporter 1 as a novel biomarker for high‐grade malignancy in prostate cancerPathology International, 2008
- Molecular prognostic factors in patients with pancreatic cancerEmerging Therapeutic Targets, 2007
- Molecular prognostic markers in pancreatic cancer: A systematic reviewEuropean Journal Of Cancer, 2005
- Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinomaJournal of Surgical Oncology, 2005
- The Effect of Apoptotic Activity, Survivin, Ki-67, and P-glycoprotein Expression on Prognosis in Pancreatic CarcinomaPancreas, 2005