Genetic Mapping in Human Disease
Top Cited Papers
- 7 November 2008
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 322 (5903), 881-888
- https://doi.org/10.1126/science.1156409
Abstract
Genetic mapping provides a powerful approach to identify genes and biological processes underlying any trait influenced by inheritance, including human diseases. We discuss the intellectual foundations of genetic mapping of Mendelian and complex traits in humans, examine lessons emerging from linkage analysis of Mendelian diseases and genome-wide association studies of common diseases, and discuss questions and challenges that lie ahead.Keywords
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