HOST-PARASITE INTERACTION IN THE RAT RENAL PELVIS
Open Access
- 1 December 1974
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 140 (6), 1696-1711
- https://doi.org/10.1084/jem.140.6.1696
Abstract
The initial interaction between bacteria and the renal pelvic epithelium may determine whether intrarenal infection occurs. A model of retrograde pyelonephritis was employed to study these events by electron microscopy. Female rats received an intravesicular inoculation of a 0.5-ml suspension of Proteus mirabilis containing 108 organisms. At intervals after inoculation, the kidneys were fixed by intravascular perfusion and the tissues were prepared for electron microscopy.Keywords
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