Context-Dependent Human Extinction Memory Is Mediated by a Ventromedial Prefrontal and Hippocampal Network
Open Access
- 13 September 2006
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 26 (37), 9503-9511
- https://doi.org/10.1523/jneurosci.2021-06.2006
Abstract
In fear extinction, an animal learns that a conditioned stimulus (CS) no longer predicts a noxious stimulus [unconditioned stimulus (UCS)] to which it had previously been associated, leading to inhibition of the conditioned response (CR). Extinction creates a new CS–noUCS memory trace, competing with the initial fear (CS–UCS) memory. Recall of extinction memory and, hence, CR inhibition at later CS encounters is facilitated by contextual stimuli present during extinction training. In line with theoretical predictions derived from animal studies, we show that, after extinction, a CS-evoked engagement of human ventromedial prefrontal cortex (VMPFC) and hippocampus is context dependent, being expressed in an extinction, but not a conditioning, context. Likewise, a positive correlation between VMPFC and hippocampal activity is extinction context dependent. Thus, a VMPFC–hippocampal network provides for context-dependent recall of human extinction memory, consistent with a view that hippocampus confers context dependence on VMPFC.Keywords
This publication has 65 references indexed in Scilit:
- Reinstatement of Conditioned Fear in Humans Is Context Dependent and Impaired in Amnesia.Behavioral Neuroscience, 2005
- Retrieving Memories via Internal Context Requires the HippocampusJournal of Neuroscience, 2004
- New Vistas on Amygdala Networks in Conditioned FearJournal of Neurophysiology, 2004
- Attention to phobic stimuli during exposure: the effect of distraction on anxiety reduction, self-efficacy and perceived controlBehaviour Research and Therapy, 2004
- Placebo-Induced Changes in fMRI in the Anticipation and Experience of PainScience, 2004
- D-Cycloserine and the Facilitation of Extinction of Conditioned Fear: Consequences for Reinstatement.Behavioral Neuroscience, 2004
- Neurons in medial prefrontal cortex signal memory for fear extinctionNature, 2002
- The role of the rat hippocampal system in several effects of context in extinction.Behavioral Neuroscience, 1995
- Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats.Behavioral Neuroscience, 1995
- A model for Pavlovian learning: Variations in the effectiveness of conditioned but not of unconditioned stimuli.Psychological Review, 1980