Studies on metabolism of vitamin A. 6. The effect of vitamin A deficiency on the activation of sulphate and its transfer to p-nitrophenol in rat liver

Abstract

Both the steps involved in the sulfurylation of phenols, namely activation and transfer of SO4, were significantly decreased in the liver supernatant of vitamin A-deficient rats. The addition of vitamin A alcohol in vitro was more effective in restoring the lost activity of the first step, whereas the acid was more effective in the second. Of the several fat-soluble compounds tried, only the different forms of vitamin A were, in various degrees, active in restoring the lost activity. After the oral administration of 3 large doses of vitamin A acetate or acid to vitamin A-deficient rats, both the enzyme activities of the liver of the 2 groups were normal.