Frequency-dependent autoinhibition of histamine release from rat cortical slices: a possible role for H3 receptor reserve
- 1 August 1988
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 40 (8), 577-579
- https://doi.org/10.1111/j.2042-7158.1988.tb05308.x
Abstract
The inhibition of histamine release after depolarization of rat cerebral cortex slices by electrical stimulation and mediated by the postulated presynaptic autoreceptor (H3) depends strongly on the conditions of stimulation. Using electrically stimulated slices of the cortex a rightwards shift of the concentration-response curve of histamine (an H3 agonist) was observed on increasing the frequency of stimulation. The pA2 value of the H3 antagonist impromidine was, however, not altered at different stimulation frequencies; for a partial agonist only the maximal effect was influenced. These results indicate the existence of a receptor reserve at the H3autoreceptor.Keywords
This publication has 7 references indexed in Scilit:
- HA autoreceptor assay with superfused slices of rat brain cortex and electrical stimulationEuropean Journal of Pharmacology, 1987
- H3 receptor assay in electrically-stimulated superfused slices of rat brain cortex; effects of Nα-alkylated histamines and impromidine analoguesInflammation Research, 1987
- Modulation of [3H]‐dopamine released by different frequencies of stimulation from rabbit retinaBritish Journal of Pharmacology, 1986
- Receptor reserve at striatal dopamine autoreceptors: Implications for selectivity of dopamine agonistsEuropean Journal of Pharmacology, 1986
- Autoregulation of histamine release in brain by presynaptic H3-receptorsNeuroscience, 1985
- Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptorNature, 1983
- Histamine Receptors in the Brain and Their Possible FunctionsPublished by Elsevier BV ,1982