Raised serum human chorionic gonadotrophin concentrations in hyperemesis gravidarum.
- 23 June 1979
- Vol. 1 (6179), 1670-1671
- https://doi.org/10.1136/bmj.1.6179.1670
Abstract
Serum human chorionic gonadotrophin (HCG) concentrations were determined by radioimmunoassay with an antiserum specific to HCG beta-subunit in 42 patients with hyperemesis gravidarum and 115 women with normal pregnancies. Mean concentrations (+/- SE of mean) were higher in the women with hyperemesis gravidarum at 7-8 weeks (40.8 +/- 5.2 IU/ml v 22.1 +/- 1.4 IU/ml; P less than 0.001), 9-11 weeks (38.1 +/- 2.3 IU/ml v 27.1 +/- 2.1 IU/ml; P less than 0.0025), and 12-14 weeks of gestation (35.9 +/- 4.2 IU/ml v 25.1 +/- 1.7 IU/ml; P less than 0.005), but there was no difference between the two groups at 15-20 weeks of gestation. In the hyperemesis gravidarum group primigravid women had a higher (P less than 0.005) mean HCG concentration (41.8 +/- 4.0 IU/ml) than multigravid women (32.2 +/- 2.3 IU/ml). The results suggest a causal relation between a high serum HCG concentration and hyperemesis gravidarum.Keywords
This publication has 7 references indexed in Scilit:
- Diagnosis and management of pregnancy by the radioreceptorassay of human chorionic gonadotropinAmerican Journal of Obstetrics and Gynecology, 1978
- Results of the First 1000 Radioreceptorassays for the Determination of Human Chorionic Gonadotropin: A New, Rapid, Reliable, and Sensitive Pregnancy TestFertility and Sterility, 1976
- A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of human luteinizing hormoneAmerican Journal of Obstetrics and Gynecology, 1972
- Nause and vomiting in pregnancyAmerican Journal of Obstetrics and Gynecology, 1968
- Urinary Excretion of Human Chorionic Gonadotrophin in Patients with Hyperemesis GravidarumBMJ, 1962
- The precision of percentiles in establishing normal limits in medicine.1958
- An investigation into the etiology of nausea and vomiting of pregnancy.1952