Effects of spleen status on early outcomes after hematopoietic cell transplantation
Open Access
- 10 December 2012
- journal article
- clinical trial
- Published by Springer Science and Business Media LLC in Bone Marrow Transplantation
- Vol. 48 (6), 825-831
- https://doi.org/10.1038/bmt.2012.249
Abstract
To assess the impact of spleen status on engraftment, and early morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT), we analyzed 9,683 myeloablative allograft recipients from 1990 to 2006; 472 had prior splenectomy (SP), 300 splenic irradiation (SI), 1,471 with splenomegaly (SM), and 7,440 with normal spleen (NS). Median times to neutrophil engraftment (NE) and platelet engraftment (PE) were 15 vs 18 days and 22 vs 24 days for the SP and NS groups, respectively (PP5.7 × 106/kg improved PE at day+28. After adjusting variables by Cox regression, the incidence of GVHD and OS were not different among groups. SM is associated with delayed engraftment, whereas SP prior to HCT facilitates early engraftment without having an impact on survival.Keywords
This publication has 32 references indexed in Scilit:
- correspondence: Splenectomy after allogeneic haematopoietic stem cell transplantation in patients with primary myelofibrosisBritish Journal of Haematology, 2010
- The role of allogeneic SCT in primary myelofibrosis: a British Society for Blood and Marrow Transplantation studyBone Marrow Transplantation, 2010
- Defining the Intensity of Conditioning Regimens: Working DefinitionsTransplantation and Cellular Therapy, 2009
- Allogeneic hemopoietic SCT for patients with primary myelofibrosis: a predictive transplant score based on transfusion requirement, spleen size and donor typeBone Marrow Transplantation, 2009
- Distribution of marrow repopulating cells between bone marrow and spleen early after transplantationBlood, 2003
- Splenic irradiation in myelofibrosis with myeloid metaplasia: a reviewBlood Reviews, 1999
- Reduced Transfusion Requirements in a Splenectomized Patient Undergoing Bone Marrow TransplantationActa Haematologica, 1994
- EFFECT OF SPLENECTOMY BEFORE BONE-MARROW TRANSPLANTATION ON SURVIVAL IN CHRONIC GRANULOCYTIC LEUKAEMIAThe Lancet, 1985
- DEATH BY GRAFT-VERSUS-HOST DISEASE ASSOCIATED WITH HLA MISMATCH, HIGH RECIPIENT AGE, LOW MARROW CELL DOSE, AND SPLENECTOMYTransplantation, 1985
- SPLENECTOMY AND BONE MARROW TRANSPLANTATION IN CHRONIC GRANULOCYTIC LEUKAEMIAThe Lancet, 1983