Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain
Open Access
- 14 November 2010
- journal article
- Published by Elsevier BV in Neurobiology of Disease
- Vol. 43 (1), 68-78
- https://doi.org/10.1016/j.nbd.2010.11.003
Abstract
No abstract availableKeywords
Funding Information
- KO Alzheimer's Disease Foundation (3G.0218.06, G.0226.09)
- VIB, Ghent University (UGent), Research Foundation Flanders (BOF09/01M00709)
- Flemish Government
- Research in the Masliah group (AG5131, AG18440)
This publication has 32 references indexed in Scilit:
- Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-SynucleinopathyPLOS ONE, 2010
- Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondriaCell Death & Disease, 2010
- The Recombinant Amyloid-β Peptide Aβ1–42 Aggregates Faster and Is More Neurotoxic than Synthetic Aβ1–42Journal of Molecular Biology, 2009
- Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body DiseasesJournal of Neuroscience, 2009
- Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xLCell Death & Differentiation, 2009
- All-you-can-eat: autophagy in neurodegeneration and neuroprotectionMolecular Neurodegeneration, 2009
- The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in miceJCI Insight, 2008
- Calpain-Cleavage of α-Synuclein: Connecting Proteolytic Processing to Disease-Linked AggregationThe American Journal of Pathology, 2007
- Suppression of basal autophagy in neural cells causes neurodegenerative disease in miceNature, 2006
- Loss of autophagy in the central nervous system causes neurodegeneration in miceNature, 2006