The Metal Chelators, Trientine and Citrate, Inhibit the Development of Cardiac Pathology in the Zucker Diabetic Rat
Open Access
- 15 April 2009
- journal article
- research article
- Published by Hindawi Limited in Experimental Diabetes Research
- Vol. 2009, 1-6
- https://doi.org/10.1155/2009/696378
Abstract
Purpose. The objective of this study was to determine the efficacy of dietary supplementation with the metal chelators, trientine or citric acid, in preventing the development of cardiomyopathy in the Zucker diabetic rat. Hypothesis. We hypothesized that dietary chelators would attenuate metal-catalyzed oxidative stress and damage in tissues and protect against pathological changes in ventricular structure and function in type II diabetes. Methods. Animals (10 weeks old) included lean control (LC, fa/Keywords
Funding Information
- South Carolina Research Foundation, University of South Carolina (DK-19971)
This publication has 41 references indexed in Scilit:
- Effects of nonselective endothelin-1 receptor antagonism on cardiac mast cell-mediated ventricular remodeling in ratsAmerican Journal of Physiology-Heart and Circulatory Physiology, 2008
- Oxidative Stress and Iron Homeostasis: Mechanistic and Health AspectsCritical Reviews in Clinical Laboratory Sciences, 2008
- Impairment of sympathetic baroreceptor reflexes in obese Zucker ratsAmerican Journal of Physiology-Heart and Circulatory Physiology, 2007
- Mechanisms for Oxidative Stress in Diabetic Cardiovascular DiseaseAntioxidants and Redox Signaling, 2007
- Triethylenetetramine and Metabolites: Levels in Relation to Copper and Zinc Excretion in Urine of Healthy Volunteers and Type 2 Diabetic PatientsDrug Metabolism and Disposition, 2006
- Molecular Changes Evoked by Triethylenetetramine Treatment in the Extracellular Matrix of the Heart and Aorta in Diabetic RatsMolecular Pharmacology, 2006
- Reactive Carbonyls and Polyunsaturated Fatty Acids Produce a Hydroxyl Radical-like SpeciesPublished by Elsevier BV ,2005
- Serum Ferritin Levels in Poorly‐ and Well‐Controlled Diabetes MellitusEndocrine Research, 2003
- Transition metals and polyol pathway in the development of diabetic neuropathy in ratsDiabetes/Metabolism Research and Reviews, 2002
- Hemodynamic determinants of the time-course of fall in canine left ventricular pressure.JCI Insight, 1976