The rat α2‐C4 adrenergic receptor gene encodes a novel pharmacological subtype
- 14 January 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 278 (1), 45-50
- https://doi.org/10.1016/0014-5793(91)80080-m
Abstract
A rat gene and brain cDNA (pA2d) encoding the homologue of the human α‐C4 adrenergic receptor subtype were isolated and characterized. RNA blots indicate that this gene is expressed in brain, heart and kidney but not in lung, liver or pancreas. Yohimbine, WB‐4101 and prasozin all exhibited high affinity for this receptor in binding studies. Clonidine was more potent and efficacious than norepinephrine in inhibiting forskolin‐stimulated cAMP production in CHO cells expressing pA2d. Together, these data suggest that the α2‐C4 gene product defines a previously undescribed pharmacological subtype α2‐adrenergic receptor.Keywords
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