Structure, Sequence and Polymorphism in the HLA‐D Region
- 1 June 1985
- journal article
- research article
- Published by Wiley in Immunological Reviews
- Vol. 85 (1), 5-44
- https://doi.org/10.1111/j.1600-065x.1985.tb01129.x
Abstract
Molecular analysis of the HLA-D region has uncovered a complex array of related genes encompassing a minimum of 6 alpha and 7 beta chain sequences. A high level of polymorphism is characteristic of the DQ alpha and beta genes, as well as DR beta. The DP genes, both alpha and beta, are also polymorphic, though to a lesser extent. The genes fit into the previously established loci: DP, DQ and DR, except for a newly-discovered sequence, DZ alpha, which is approximately equally related to all of the other alpha chain genes. Analysis of the polymorphism and evolution of the HLA-D region, by examination of the sequences, calls for several independent duplication events in the generation of this family of genes.Keywords
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