DIFFERENT EFFECTS ON RENAL AND SUBMAXILLARY RENIN RELEASE AFTER BLOCKADE OF THE RENIN SYSTEM IN MICE

Abstract

Inhibition of the angiotensin I converting enzyme with SQ 20,881 [Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro] rapidly increased plasma renin concentration in mice. The maximum effect is short-lasting, but the values are still elevated 2 h after the injection, the time course being similar to that previously found in rats. The relative increase is the same in normal and sialo-adrenectomized mice. The plasma renin concentration of nephrectomized mice with their submaxillary glands intact is, however, totally uninfluenced by injection of the blocker. Renin release from the submaxillary glands is probably not controlled by the plasma angiotensin II concentration as is that of the renin release from the kidneys.