THE CASE to be described is the first in the literature in which the development of carcinoma of the vulva secondary to granuloma inguinale is without doubt. There are in the literature, however, case reports of squamous cell carcinoma of the genitalia that developed at sites previously involved by granuloma inguinale, but none in which this sequence of events can go unquestioned with regard to the vulva itself. REPORT OF A CASE W. G. (No. 38-901), a 16-year-old Negro girl, was admitted to the clinic on Oct. 14, 1938, because of multiple lesions of the vulva of approximately six months' duration. The lesions were granulomatous, beefy red, and covered with a serosanguineous exudate; they involved the fourchette of the vagina, a part of the right vaginal wall, the right labium minus and labium majus, the right genitocrural fold, and in great part the right inguinal region. There were